Encyclopedia

POLR2G

Protein-coding gene in the species Homo sapiens

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Source updated July 17, 2025

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DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the POLR2G gene.

This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, the association of this subunit with the polymerase under suboptimal growth conditions indicates it may play a role in regulating polymerase function.

01Interactions

POLR2G has been shown to interact with TAF15, POLR2C, POLR2H and POLR2E.

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Sources and credits

This article is adapted from the Wikipedia article “POLR2G”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Protein POLR2G PDB 2c35.png by Emw, CC BY-SA 3.0

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