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Phosphodiesterase 4

Index of chemical compounds with the same name

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated July 2, 2022

At least four types of the enzyme phosphodiesterase 4 (PDE4) are known:

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This article is adapted from the Wikipedia article “Phosphodiesterase 4”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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3',5'-cyclic-AMP phosphodiesterase

3′,5′-cyclic-AMP phosphodiesterase is an enzyme with systematic name 3′,5′-cyclic-AMP 5′-nucleotidohydrolase. It catalyses the following reaction The enzyme characterised from Escherichia coli and mammalian cardiac tissue hydrolyses cyclic adenosine monophosphate to adenosine monophosphate.

Phosphodiesterase

A phosphodiesterase is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

PDE4 inhibitor

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors.