PDE4D
Protein-coding gene in the species Homo sapiens
cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.
01Function
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM]
02Interactions
PDE4D has been shown to interact with myomegalin and GNB2L1.
03Clinical relevance
Mutations in this gene have been associated to cases of acrodysostosis.
This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.
Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker.
Sources and credits
This article is adapted from the Wikipedia article “PDE4D”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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