MiPBF
Pharmaceutical compound
MiPBF, also known as N-methyl-N-isopropyl-3-(2-aminoethyl)benzofuran or as 1-oxa-N-methyl-N-isopropyltryptamine (1-oxa-MiPT), is a serotonin receptor modulator of the benzofuran family related to the psychedelic tryptamine methylisopropyltryptamine (MiPT). It is the analogue and bioisostere of MiPT in which the indole nitrogen has been replaced with an oxygen atom, making it a benzofuran rather than tryptamine derivative. The drug shows affinity for serotonin receptors, including the serotonin 5-HT1A, 5-HT2A, and 5-HT2B receptors (IC50Tooltip half-maximal inhibitory concentration = 5,000 nM, 500 nM, and 800 nM, respectively). Its affinities for these receptors were 7-fold, 13-fold, and 1.5-fold lower than those of MiPT, respectively. MiPBF was first described in the scientific literature by Dennis McKenna and David Repke and colleagues in 1990.
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This article is adapted from the Wikipedia article “MiPBF”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- MiPBF.svg by User:Innerstream, Public domain
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