David Repke
Chemist
David Repke, or David B. Repke, is an American medicinal chemist who has done work in the area of psychedelic drugs. He and his colleagues are known to have been the first to synthesize and describe a number of notable psychedelic tryptamines, including 4-HO-MET, 4-HO-MPT, 4-HO-DPT, 4-HO-DBT, 4-HO-DiPT, MiPT, 4-HO-MiPT, 5-MeO-MiPT, 4-HO-McPeT, and 4-HO-pyr-T, among others. He is known to have collaborated with Alexander Shulgin and Dennis McKenna on scientific work. Both Repke and Shulgin conducted self-experimentation with the novel psychedelics they developed. Repke has also published a book on the entheogenic use of Anadenanthera in South America that was coauthored with Constantino Manuel Torres.
01Selected publications
Books
- Torres, Constantino Manuel; Repke, David B. (2006). Anadenanthera: Visionary Plant of Ancient South America. Routledge. doi:10.4324/9781315864594. ISBN 978-1-315-86459-4.
Journal articles
- Repke, David B.; Ferguson, Wilfred J. (1976). "Synthesis of S (+) and R (-)-3-(2-aminopropyl)indole from ethyl- D - and L -tryptophanate". Journal of Heterocyclic Chemistry. 13 (4): 775, 778. doi:10.1002/jhet.5570130417. ISSN 0022-152X. Retrieved 8 October 2025.
- Repke, David B.; Leslie, Dale Thomas (1977). "Baeocystin in Psilocybe semilanceata". Journal of Pharmaceutical Sciences. 66 (1): 113, 114. Bibcode:1977JPhmS..66..113R. doi:10.1002/jps.2600660130. PMID 556766. Retrieved 8 October 2025.
- Ferguson WJ, Bates DK, Repke DB (1977). "Psilocin analogs. 1. Synthesis of 3-[2-(dialkylamino)ethyl] -and 3-[2-(cycloalkylamino)ethyl] indol-4-ols". Journal of Heterocyclic Chemistry. 14 (1): 71, 74. doi:10.1002/jhet.5570140113. ISSN 0022-152X.
- Repke DB, Ferguson WJ, Bates DK (1981). "Psilocin analogs II. Synthesis of 3-[2-(dialkylamino)ethyl]-, 3-[2-(N-methyl-N-alkylamino)ethyl]-, and 3-[2-(cycloalkylamino)ethyl]indol-4-ols". Journal of Heterocyclic Chemistry. 18 (1): 175, 179. doi:10.1002/jhet.5570180131. ISSN 0022-152X.
- Repke, David B.; Ferguson, Wilfred J. (1982). "Psilocin analogs. III. Synthesis of 5-methoxy- and 5-hydroxy-1,2,3,4-tetrahydro-9 H -pyrido[3,4- b ]indoles". Journal of Heterocyclic Chemistry. 19 (4): 845, 848. doi:10.1002/jhet.5570190428. ISSN 0022-152X. Retrieved 8 October 2025.
- Repke DB, Grotjahn DB, Shulgin AT (July 1985). "Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents". J Med Chem. 28 (7): 892, 896. doi:10.1021/jm00145a007. PMID 4009612.
- McKenna DJ, Repke DB, Peroutka SJ (1989). "Hallucinogenic indolealkylamines are selective for 5HT2A binding sites". Neuroscience Abstract. 15: 485-.
- McKenna DJ, Repke DB, Lo L, Peroutka SJ (March 1990). "Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes". Neuropharmacology. 29 (3): 193, 198. doi:10.1016/0028-3908(90)90001-8. PMID 2139186.
- Torres, Constantino Manuel; Repke, David B.; Chan, Kelvin; McKenna, Dennis; Llagostera, Agustin; Schultes, Richard Evans (1991). "Snuff Powders from Pre-Hispanic San Pedro de Atacama: Chemical and Contextual Analysis". Current Anthropology. 32 (5): 640, 649. doi:10.1086/204014. ISSN 0011-3204. Retrieved 8 October 2025.
- Repke, David B.; Artis, Dean R.; Nelson, Janis T.; Wong, Erik H. F. (1994). "Abbreviated Ibogaine Congeners. Synthesis and Reactions of Tropan-3-yl-2- and -3-indoles. Investigation of an Unusual Isomerization of 2-Substituted Indoles Using Computational and Spectroscopic Techniques". The Journal of Organic Chemistry. 59 (8): 2164, 2171. doi:10.1021/jo00087a037. ISSN 0022-3263. Retrieved 8 October 2025.
Book chapters
- Torres CM, Repke D (1996). "The use of Anadenanthera colubrina var. cebil by Wichi (Mataco) Shamans of the Chaco Central, Argentina". Jahrbuch für Ethnomedizin und Bewußtseinsforschung [Yearbook for Ethnomedicine and the Study of Consciousness]. Vol. 5. pp. 41, 58.
Sources and credits
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