Alpha-actinin-1
Protein-coding gene in the species Homo sapiens
01Function
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein, a bundling protein that is thought to anchor actin to a number of intracellular structures. Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
02Interactions
Alpha-actinin-1 has been shown to interact with:
- CDK5R1,
- CDK5R2,
- Collagen, type XVII, alpha 1,
- GIPC1,
- PDLIM1,
- Protein kinase N1,
- SSX2IP, and
- Zyxin.
- PTPRT (PTPrho)
Sources and credits
This article is adapted from the Wikipedia article “Alpha-actinin-1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 14.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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