5-MeO-NET

5-MeO-NET was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).

Pharmacodynamics

5-MeO-NET is a potent full agonist or near-full agonist of the serotonin 5-HT_1A, 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors. The drug is a relatively weak serotonin releasing agent.

It does not produce the head-twitch response (HTR), a behavioral proxy of psychedelic effects, in rodents, suggesting that it would not be hallucinogenic in humans. However, 5-MeO-NET does produce the HTR if it is coadministered with a serotonin 5-HT_1A receptor antagonist like WAY-100635, suggesting that its serotonin 5-HT_1A receptor agonism masks or blocks its own serotonin 5-HT_2A receptor-mediated HTR induction.

5-MeO-NET, chemically known as 5-methoxy-N-ethyltryptamine, is a synthetic substituted tryptamine and a N-Ethyltryptamine derivative.

Analogues

Analogues of 5-MeO-NET include N-Ethyltryptamine (NET), 4-HO-NET, 4-AcO-NET, αET, 4-HO-αET, 5-MeO-αET, 5-chloro-αMT (PAL-542), 5-fluoro-αET (PAL-545), 5-MeO-MET, 5-MeO-DMT, 5-MeO-DET, 5-MeO-MPT, 5-MeO-EPT, 5-MeO-MALT, and 5-MeO-MiPT, among others.

5-MeO-NET was first described in the scientific literature by at least 1994. Research on 5-MeO-NET since the early 2000s has primarily focused on its interactions with serotonin receptors and other targets, as well as behavioral effects in rodent models.