4-HO-NET
Pharmaceutical compound
4-HO-NET, also known as 4-hydroxy-N-ethyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT). It was not included by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown. The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor. It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 13-fold lower potency than psilocin (4-HO-DMT). Unlike 4-HO-NET, norpsilocin is notably inactive in this test. In addition to its psychedelic-like effects, 4-HO-NET produces hypolocomotion and hypothermia in rodents. 4-HO-NET was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.
Sources and credits
This article is adapted from the Wikipedia article “4-HO-NET”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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- 4-HO-NET.svg by User:Innerstream, Public domain
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