ZFX
Protein-coding gene in the species Homo sapiens
Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.
01Function
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome (ZFY). It encodes a member of the krüppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
02Clinical significance
The gene is associated with X-linked neurodevelopmental disorder.
Sources and credits
This article is adapted from the Wikipedia article “ZFX”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Protein ZFX PDB 5znf.png by Emw, CC BY-SA 3.0
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