XPA
Protein-coding gene in the species Homo sapiens
DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene.
01Function
Nucleotide excision repair (NER) is a major pathway for repairing a variety of bulky DNA damages including those introduced by UV irradiation. The XPA protein appears to play a key role in NER at sites of damage as a scaffold for other repair proteins in order to ensure that the damages are appropriately excised.
XPA binds with affinity to irradiated DNA, those with "bulky adducts and cisplatin lesions, and DNA duplexes with loops and bulges.
Among the repair proteins with which XPA interacts is a protein complex (including the ERCC1 protein) that is capable of incising DNA at sites of damage.
Xpa mutant individuals often show the severe clinical symptoms of xeroderma pigmentosum, a condition involving extreme sensitivity to sunlight and a high incidence of skin cancer.
02Interactions
XPA has been shown to interact with ERCC1, Replication protein A1 and XAB2.
XPA4-97, the N-terminus, has binding regions for Replication protein A 34 and ERCC1. The C-terminal domain XPA226-273 and Transcription factor II H interact. The DNA-binding domain is found in the central domain (XPA98-219).
Sources and credits
This article is adapted from the Wikipedia article “XPA”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Protein XPA PDB 1d4u.png by Emw, CC BY-SA 3.0
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.