WDR75
Protein-coding gene in the species Homo sapiens
(See also: List of proteins in the human body)WDR75 is a human protein encoded by the WDR75 gene containing a WD40 superfamily domain. The WD40 domain is found throughout many eukaryotic cell types and is known to be involved in cellular regulator functions such as pre-mRNA processing and cytoskeleton assembly. The function of the WDR75 protein is not defined by the scientific community.
| Accession numbers | Location | Identifiers | M.W. | pI |
|---|---|---|---|---|
| NM_032186, NP_115544.1 | 2q32.2 | FLJ12519, DKFZp781N2144 | 94.5 kDa | 5.56 |
01Protein sequence
The amino acid sequence is 830 residues long and contains an acidic tail.
1 MVEEENIRVV RCGGSELNFR RAVFSADSKY IFCVSGDFVK VYSTVTEECV HILHGHRNLV 61 TGIQLNPNNH LQLYSCSLDG TIKLWDYIDG ILIKTFIVGC KLHALFTLAQ AEDSVFVIVN 121 KEKPDIFQLV SVKLPKSSSQ EVEAKELSFV LDYINQSPKC IAFGNEGVYV AAVREFYLSV 181 YFFKKKTTSR FTLSSSRNKK HAKNNFTCVA CHPTEDCIAS GHMDGKIRLW RNFYDDKKYT 241 YTCLHWHHDM VMDLAFSVTG TSLLSGGRES VLVEWRDATE KNKEFLPRLG ATIEHISVSP 301 AGDLFCTSHS DNKIIIIHRN LEASAVIQGL VKDRSIFTGL MIDPRTKALV LNGKPGHLQF 361 YSLQSDKQLY NLDIIQQEYI NDYGLIQIEL TKAAFGCFGN WLATVEQRQE KETELELQMK 421 LWMYNKKTQG FILNTKINMP HEDCITALCF CNAEKSEQPT LVTASKDGYF KVWILTDDSD 481 IYKKAVGWTC DFVGSYHKYQ ATNCCFSEDG SLLAVSFEEI VTIWDSVTWE LKCTFCQRAG 541 KIRHLCFGRL TCSKYLLGAT ENGILCCWNL LSCALEWNAK LNVRVMEPDP NSENIAAISQ 601 SSVGSDLFVF KPSEPRPLYI QKGISREKVQ WGVFVPRDVP ESFTSEAYQW LNRSQFYFLT 661 KSQSLLTFST KSPEEKLTPT SKQLLAEESL PTTPFYFILG KHRQQQDEKL NETLENELVQ 721 LPLTENIPAI SELLHTPAHV LPSAAFLCSM FVNSLLLSKE TKSAKEIPED VDMEEEKESE 781 DSDEENDFTE KVQDTSNTGL GEDIIHQLSK SEEKELRKFR KIDYSWIAAL02Secondary structure
The secondary structure is predicted to contain alternating sets of alpha helices and beta strands. No helix-turn-helix (HTH) regions were predicted.
03Homology
No known paralogs exist for the Human gene. No paralogs were found for the cow, mouse, or rat orthologs of WDR75. Conservation among mammalian orthologs to the human gene was strong, with minimum identity among orthologs at 76%. The following table summarizes some vertebrate and invertebrate orthologs. Conservation of specific amino acids from positions 340-390, 430- 450, and 515-530 all correlate to predicted alpha helices.
| Organism | Accession number | % Identity to Human Gene |
|---|---|---|
| Bos Taurus | NP_001095532.1 | 91.7 |
| Mus musculus | NP_082875.1 | 84.9 |
| Pan troglodytes | XP_001164827.1 | 99.5 |
| Rattus norvegicus | NP_001041354.1 | 84.3 |
| Canis familiaris | XP_545565 | 90.7 |
| Xenopus Laevis | NP_001086564.1 | 61.0 |
| Gallus gallus | XP_001233408.1 | 60.8 |
| Schizosaccharomyces pombe | NP_594798 | 19.9 |
| Anopheles gambiae | XP_317524 | 22.7 |
Sources and credits
This article is adapted from the Wikipedia article “WDR75”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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