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USF2

Protein-coding gene in the species Homo sapiens

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Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.

01Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.

02Interactions

USF2 has been shown to interact with USF1 (human gene), PPRC1 and BRCA1.

03Regulation

The USF2 gene is repressed by the microRNA miR-10a.

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Sources and credits

This article is adapted from the Wikipedia article USF2, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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