UPF1
Protein-coding gene in the species Homo sapiens
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog) is a protein that in humans is encoded by the UPF1 gene.
01Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in both the cytoplasm and nucleus. When translation ends, it interacts with the functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “UPF1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.