Tomatidine
Chemical compound
Tomatidine is a natural compound found in leaves of tomatoes and green tomatoes. Chemically, it is the aglycone of tomatine. It has been shown to have potential health benefits in animal models. For instance, tomatidine inhibited skeletal muscle atrophy in a mouse model of skeletal unloading-induced atrophy and to prevent or reverse sarcopenia (loss of muscle mass and strength due to biological aging) by inhibiting the activation of genes by ATF4.
Dietary supplementation with ~0.04% tomatidine for 10 weeks reduced plasma cholesterol and atherosclerosis in ApoE-deficient mice without evidence of toxicity.
01Research
It is investigated as compound to increase longevity and it increased lifespan and healthspan of C. elegans. It is also investigated in osteoporosis.
Sources and credits
This article is adapted from the Wikipedia article “Tomatidine”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Tomatidine.svg by User:Innerstream, Public domain
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