Tyrosyl-DNA phosphodiesterase 2
Enzyme found in humans
Tyrosyl-DNA phosphodiesterase 2 is an enzyme that in humans is encoded by the gene TDP2 (previously TTRAP). The TDP2 protein functions as a DNA repair enzyme by removing covalent adducts from DNA. It functions in a similar role to the TDP1 enzyme, but it preferentially acts on 5'-phosphodiester bonds, while TDP1 is the faster and more efficient enzyme for 3'-phosphodiester bonds.
This protein is a member of a superfamily of divalent cation-dependent phosphodiesterases. It associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
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Sources and credits
This article is adapted from the Wikipedia article “Tyrosyl-DNA phosphodiesterase 2”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 6.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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