Reference articles on history, science, culture and more
Encyclopedia

TRIP6

Protein-coding gene in the species Homo sapiens

Image credit is listed at the end of this article.

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.

01Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

02Interactions

TRIP6 has been shown to interact with LPAR2, BCAR1 and HOXA9.

Watch videos about TRIP6Explainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article TRIP6, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.