Transcription factor II E
Transcription factor
| general transcription factor IIE, polypeptide 2, beta 34kDa | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GTF2E2 | ||||||
| Alt. symbols | TF2E2 | ||||||
| NCBI gene | 2961 | ||||||
| HGNC | 4651 | ||||||
| OMIM | 189964 | ||||||
| RefSeq | NM_002095 | ||||||
| UniProt | P29084 | ||||||
| Other data | |||||||
| Locus | Chr. 8 p12 | ||||||
| |||||||
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.
Sources and credits
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