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Sorting nexin

Protein domain

Wikipedia contributorsAdapted for Fathomly · View authors
2 min read
Source updated February 19, 2022
Image credit is listed at the end of this article.
Sorting nexin, N-terminal domain
Identifiers
SymbolSorting_nexin
PfamPF03700
InterProIPR005329
Available protein structures:
PDB  IPR005329 PF03700 (ECOD; PDBsum)  
AlphaFold
Vps5 C terminal like (BAR domain)
Identifiers
SymbolVps5
PfamPF09325
InterProIPR015404
Available protein structures:
PDB  IPR015404 PF09325 (ECOD; PDBsum)  
AlphaFold
Sorting nexin, C terminal domain
Identifiers
SymbolNexin_C
PfamPF08628
InterProIPR013937
Available protein structures:
PDB  IPR013937 PF08628 (ECOD; PDBsum)  
AlphaFold
WASP-binding domain of Sorting nexin protein
Identifiers
SymbolBAR3-WASP
PfamPF10456
Available protein structures:
PDB  PF10456 (ECOD; PDBsum)  
AlphaFold

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein-protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

01Family members

In humans, sorting nexins are transcribed from the following genes:

Genes Domain Composition
N-terminus Mid-1 Mid-2 Mid-3 C-terminus
SNX1, SNX2 Sorting_nexin_N , PX , BAR (Vps5)
SNX4, SNX7, SNX8, SNX30 , , PX , BAR (Vsp5)
SNX5, SNX6, SNX32 , , PX , BAR
SNX9, SNX18, SNX33 SH3 , PX , BAR (BAR_3_WASP_bdg)
SNX13, SNX14, SNX19, SNX25 PXA RGS PX , Nexin_C
SNX15 , , PX , MIT
SNX17, SNX31 , , PX RA FERM_M
SNX23 kinesin_motor SMAD_FHA PX , ,
SNX26 , , PX SH3 RhoGAP
SNX27 PDZ , PX - FERM_M
SNX28 , , PX SH3 SH3
SNX3, SNX10, SNX11, SNX12, SNX16, SNX20, SNX21, SNX22, SNX24, SNX29 , , PX , ,
Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1). NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.
Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1). NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.

02Structure

Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.

A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)

An example of a sorting nexin domain structure can be seen here for SNX1:

  1. NTD, N-terminal domain
  2. PX domain
  3. CTD, C-terminal BAR domain
Watch videos about Sorting nexinExplainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “Sorting nexin”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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