Saksi

Saksi premiered on October 2, 1995, with Mike Enriquez and Karen Davila as its original anchors.

On July 8, 1996, Mel Tiangco joined the show. Segment reporters who also joined the show include Solita "Winnie" Monsod for Mareng Winnie, Kara David for Huling Hirit, Lyn Ching for S na S (Showbiz sa Saksi) and Jessica Soho for Jessica Soho Reports. In 1998, when Enriquez and Davila left the show, Jay Sonza and Luchi Cruz-Valdes joined the show.

On August 16, 1999, Enriquez returned to the program, whereas Vicky Morales joined the show. This was also the beginning of simulcasting the newscast on the network's radio station, Super Radyo DZBB 594 kHz. On July 15, 2002, Howie Severino joined the show as anchor of segment Side Trip. In the same year, Saksi won the gold medal for Best Newscast in the New York Festival, becoming one of the few news programs outside the United States to receive the said honor. The award was later recognized by the Philippine Congress by issuing the network a commendation for its work in News and Public Affairs. On March 12, 2004, Enriquez left the newscast to join Frontpage: Ulat ni Mel Tiangco anchor Tiangco as anchors of 24 Oras. Three days later, Arnold Clavio joined as the new host.

The show launched a segment called Saksi Ako (transl. I am a witness), where viewers can make their own report there by using cellphone and camera recordings via GMA Network app's Youscoop. In July 2013, it launched its segment Midnight Snack, a food-trip segment hosted by Mikael Daez every Mondays to Thursdays, After a one-week hiatus, On November 5, 2013, it returned under the new title Midnight Express.

In November 2014, Pia Arcangel joined as an co-anchor, replacing Morales. In April 2020, the show was suspended due to the enhanced community quarantine in Luzon caused by the COVID-19 pandemic. The show resumed its programming on June 1, 2020.

On June 12, 2024, Clavio temporarily left the newscast due to his hemorrhagic stroke.

On October 28, 2024, due to GMA Integrated News' cost reduction, Arcangel became the sole anchor of the news show. Clavio also left the show, to reduce his working time.

• Pia Arcangel (since 2014)
• Amor Larrosa (since 2023, GMA Integrated News Weather Center)

Former anchors

• Mike Enriquez (1995-2004)
• Karen Davila (1995-98)
• Mel Tiangco (1996-99)
• Winnie Monsod (1996-99, Mareng Winnie)
• Lyn Ching (1996-99, S na S: Showbiz na Saksi)
• Kara David (1996-99, Huling Hirit)
• Jessica Soho (1996-99, Jessica Soho Reports)
• Amado Pineda (1995-96, weatherman)
• Rey Pacheco (1996-99, weatherman)
• Jay Sonza (1998-99)
• Luchi Cruz-Valdes (1998-99)
• Vicky Morales (1999-2014)
• Howie Severino (2002, Side Trip)
• Bernadette Sembrano (2003)
• Arnold Clavio (2004-24)
• Mikael Daez (2013-23, Midnight Express)

Interim anchors

• Luchi Cruz-Valdes (1995-2002)
• Jay Taruc (1997-98)
• Sandra Aguinaldo (2013-23)
• Lala Roque (2013-16)
• Rhea Santos (2013)
• Mariz Umali (2013, 2017-23)
• Tina Panganiban-Perez (2013, 2019-24)
• Kara David (2013-14)
• Ivan Mayrina (2013)
• Jun Veneracion (2014-21)
• Raffy Tima (2013, 2019-23)
• Susan Enriquez (2017, 2018-20)
• Chino Gaston (2020-23)
• Emil Sumangil (2016, 2019, 2021)
• Joseph Morong (2012, 2019-21)
• Oscar Oida (2015, 2019)
• Maki Pulido (2012-13)
• Mark Salazar (2012, 2015)
• Connie Sison (2023)
• Ian Cruz (2023)
• Atom Araullo (2023)
• Mav Gonzales (2023)

• Barangay Saksi
• Bonus Shot
• Midnight Express
• News Bullets (Mabilis na Sulyap)
• Sakcess
• Showbiz Saksi
• Sports Saksi
• Good Night Vibes

Defunct

• Bisig Bayan
• Huling Hirit
• Jessica Soho Reports
• Mareng Winnie
• Midnight Snack
• S na S: Showbiz na Saksi
• Side Trip