STAMBP
Protein-coding gene in the species Homo sapiens
01Function
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
02Clinical significance
Mutations in this gene have been associated with a unique congenital progressive encephalopathy known as MIC-CAP.
03Interactions
STAMBP has been shown to interact with RNF11, Signal transducing adaptor molecule and GRAP2.
Sources and credits
This article is adapted from the Wikipedia article “STAMBP”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram house mouse chromosome 6.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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