SPPL2B
Protein-coding gene in the species Homo sapiens
Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.
01Gene
Multiple transcript variants encoding different isoforms have been found for this gene.
02Subcellular distribution
This enzyme localizes to endosomes, lysosomes, and the plasma membrane.
03Structure
This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs).
04Function
This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. SPPL2b also modulates APP cleavage and Aβ production.
Sources and credits
This article is adapted from the Wikipedia article “SPPL2B”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 19.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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