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NHP2L1

Protein-coding gene in the species Homo sapiens

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Source updated July 16, 2025

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NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene.

01Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.

02Interactions

SNU13 has been shown to interact with RAD17.

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Sources and credits

This article is adapted from the Wikipedia article “NHP2L1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Protein NHP2L1 PDB 1e7k.png by Emw, CC BY-SA 3.0

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