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SENP2

Protein-coding gene in the species Homo sapiens

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Source updated July 17, 2025

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Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.

01Function

SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of protease enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM]

02Interactions

SENP2 has been shown to interact with NUP153.

Watch videos about SENP2Explainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “SENP2”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Protein SENP2 PDB 1tgz.png by Emw, CC BY-SA 3.0

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