RLIM
Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene (previously RNF12).
01Function
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported. The protein functions in female mice as a regulator of X chromosome inactivation.
02Interactions
The RLIM protein has been shown to interact with Estrogen receptor alpha.
Sources and credits
This article is adapted from the Wikipedia article “RLIM”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome X.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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