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RGS19

Protein-coding gene in the species Homo sapiens

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Source updated July 15, 2025

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Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.

01Interactions

RGS19 has been shown to interact with GNAO1, GIPC1, OSTM1, GNAI1, GNAI3 and GNAZ.

Watch videos about RGS19Explainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “RGS19”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Protein RGS19 PDB 1cmz.png by Emw, CC BY-SA 3.0

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