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Pyr-AI

Pharmaceutical compound

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated November 4, 2025
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Pyr-AI, also known as 2-pyrrolidinylindane (2-PYI), is a stimulant drug of the 2-aminoindane family. It is the analogue of 2-aminoindane (2-AI) in which the amine has been replaced with a pyrrolidine group. The drug has been described as having strong and long-lasting amphetamine-like effects in rodents. Other 2-aminoindanes like 2-AI itself and NM-2-AI are known to act as potent monoamine releasing agents and reuptake inhibitors. Pyr-AI was first described in the scientific literature by 1973.

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This article is adapted from the Wikipedia article “Pyr-AI”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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Substituted 2-aminoindane

A substituted 2-aminoindane is a derivative of 2-aminoindane with one or more chemical substituents. They are cyclized phenethylamines and are structurally related to amphetamines like amphetamine and MDMA. Many 2-aminoindanes are known to act as monoamine releasing agents and/or receptor modulators.

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