Pituitary-specific positive transcription factor 1
Protein that controls rate of transcription of GH genes
POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.
01Function
PIT1 is part of the POU family of transcription factors. It is expressed by somatotrophic cells, as well as thyrotrophs and lactotrophs of the anterior pituitary gland. It contains a C-terminal domain for transactivation. Another domain is DNA binding, its C-terminal portion is homologous to the homeodomain consensus, common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the prolactin and growth hormone genes and is involved in protein-protein interactions. Activity on thyroid stimulating hormone-beta expression is also known for PIT1.
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “Pituitary-specific positive transcription factor 1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.