PEX14
Protein-coding gene in the species Homo sapiens
| Peroxisomal membrane anchor protein (Pex14p) conserved region | |
|---|---|
| Identifiers | |
| Symbol | Pex14_N |
| Pfam | PF04695 |
| InterPro | IPR006785 |
Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.
01Function
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “PEX14”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Protein PEX14 PDB 2W84.png by Pleiotrope, Public domain
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