PDCD10
Protein-coding gene in the species Homo sapiens
Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene.
01Function
This gene encodes a protein, originally identified in a premyeloid cell line, with similarity to proteins that participate in apoptosis. Three alternative transcripts encoding the same protein, differing only in their 5' UTRs, have been identified for this gene.
02Gene
Loss of function mutations in PDCD10 result in the onset of Cerebral Cavernous Malformations (CCM) illness. Therefore, this gene is also called CCM3. Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and spinal cord made of dilated capillary vessels.
03Interactions
CCM3 encodes a protein called Programmed Cell Death 10 (PDCD10). The function of this protein has only recently begun to be understood. PDCD10 has roles in vascular development and VEGF signaling1, apoptosis and functions as part of a larger signaling complex that includes germinal center kinase III. Specifically, PDCD10 has been shown to interact with STK26, STK25, STRN, STRN3, MOBKL3, CTTNBP2NL, STK24 and FAM40A.
Sources and credits
This article is adapted from the Wikipedia article “PDCD10”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Protein PDCD10 PDB 3AJM.png by Pleiotrope, Public domain
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