PARD3
Protein-coding gene in the species Homo sapiens
01Function
PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “PARD3”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Protein PARD3 PDB 2KOM.png by Jensen, D.R., Woytovich, C., Li, M., Duvnjak, P., Cassidy, M.S., Frederick, R.O., Bergeman, L.F., Peterson, F.C., Volkman, B.F(2010). Rapid, robotic, small-scale protein production for NMR screening and structure determination. Journal: (2010) Protein Sci. 19: 570-578, GPL
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