Neoendorphin
Class of opioid peptides
Neoendorphins are a group of endogenous opioid peptides derived from the proteolytic cleavage of prodynorphin. They include α-neoendorphin and β-neoendorphin. The α-neoendorphin is present in greater amounts in the brain than β-neoendorphin. Both are products of the dynorphin gene, which also expresses dynorphin A, dynorphin A1-8, and dynorphin B. These opioid neurotransmitters are especially active in CNS receptors, whose primary function is pain sensation. These peptides all have the consensus amino acid sequence of Tyr-Gly-Gly-Phe-Met (met-enkephalin) or Tyr-Gly-Gly-Phe-Leu (leu-enkephalin). Binding of neoendorphins to opioid receptors, in the dorsal root ganglion (DRG) neurons results in the reduction of time of calcium-dependent action potential. The α-neoendorphins binds to μ-opioid, δ-opioid, κ-opioid receptor (KOR), cand β-neoendorphin binds to KOR.
01Types
| Sequence | Molecular Formula | |
|---|---|---|
| α-neoendorphin | H-Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys-OH | C60H89N15O13 |
| β-neoendorphin | H-Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-OH | C54H77N13O12 |
Sources and credits
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