Nucleoporin 43
Protein-coding gene in the species Homo sapiens
Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004).[supplied by OMIM] Along with other nucleoporins.
01Structure
It folds into a canonical WD40 repeat domain.
02Disease association
High expression of NUP43 in breast cancer is associated with poor overall survival. In chronic myelogenous leukemia (CML), reduction of miRNA-409-5p increases the expression of NUP43 that in turn enhances proliferative potential, cell cycle progression, and imatinib resistance.
Some Nup43 variants have been characterized as causal for the onset of cardiovascular disease (CVD), while Nup43 expression has been associated with attention deficit hyperactivity disorder.
Sources and credits
This article is adapted from the Wikipedia article “Nucleoporin 43”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 6.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.