NFS1
Protein-coding gene in the species humans Homo sapiens
Cysteine desulfurase, mitochondrial is an enzyme that in humans is encoded by the NFS1 gene.
Iron-sulfur clusters are required for the function of many cellular enzymes. The protein encoded by this gene supplies inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine and a protein-bound hydropersulfide in the process. The terminal sulfur atom of the hydropersulfide is transferred to the iron-sulfur cluster scaffold protein ISCU, mediated by the accessory protein frataxin.
This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded protein belongs to the class-V family of pyridoxal phosphate-dependent aminotransferases.
Sources and credits
This article is adapted from the Wikipedia article “NFS1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 20.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.