Norfenefrine
Trace amine
Norfenefrine, also known as meta-octopamine or norphenylephrine and sold under the brand name Novadral among others, is a sympathomimetic medication which is used in the treatment of hypotension (low blood pressure). Along with its structural isomer p-octopamine and the tyramines, norfenefrine is a naturally occurring endogenous trace amine and plays a role as a minor neurotransmitter in the brain.
01Medical uses
Norfenefrine is used in the treatment of hypotension (low blood pressure). It is said to be similarly effective or less effective than midodrine.
02Pharmacology
Pharmacodynamics
Norfenefrine is described as an α-adrenergic receptor agonist and sympathomimetic agent. It is said to act predominantly as an α1-adrenergic receptor agonist.
03Chemistry
Norfenefrine, also known as 3,β-dihydroxyphenethylamine, is a substituted phenethylamine derivative. It is an analogue of norepinephrine (3,4,β-trihydroxyphenethylamine), of meta-tyramine (3-hydroxyphenethylamine), of phenylephrine ((R)-β,3-dihydroxy-N-methylphenethylamine), of etilefrine (3,β-dihydroxy-N-ethylphenethylamine), and of metaterol (3,β-dihydroxy-N-isopropylphenethylamine), as well as of metaraminol ((1R,2S)-3,β-dihydroxy-α-methylphenethylamine).
Norfenefrine is used medically as the hydrochloride salt.
The predicted log P of norfenefrine is -0.28 to -0.95.
04Society and culture
Names
Norfenefrine is the generic name of the drug and its INNTooltip International Nonproprietary Name. Synonyms of norfenefrine include hydroxyphenylethanolamine, nor-phenylephrine, and m-norsynephrine, among others. Brand names of norfenefrine include Novadral, A.S. COR, Coritat, Energona, Hypolind, Norfenefrin Ziethen, and Norfenefrin-Ratiopharm, among others.
Availability
Sources and credits
This article is adapted from the Wikipedia article “Norfenefrine”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Norfenefrine.png by Edgar181, Public domain
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.