Manhattan plot
Method to display data used in genetic analysis
A Manhattan plot is a type of plot, usually used to display data with a large number of data-points, many of non-zero amplitude, and with a distribution of higher-magnitude values. The plot is commonly used in genome-wide association studies (GWAS) to display significant SNPs.
It gains its name from the similarity of such a plot to the Manhattan skyline: a profile of skyscrapers towering above the lower level "buildings" which vary around a lower height.
01GWAS
In GWAS Manhattan plots, genomic coordinates are displayed along the x-axis, with the negative logarithm of the association p-value for each single nucleotide polymorphism (SNP) displayed on the y-axis, meaning that each dot on the Manhattan plot signifies an SNP. Because the strongest associations have the smallest p-values (e.g., 10−15), their negative logarithms will be the greatest (e.g., 15). The different colors of each block usually show the extent of each chromosome.
Sources and credits
This article is adapted from the Wikipedia article “Manhattan plot”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Manhattan Plot.png by M. Kamran Ikram et al, CC BY 2.5
Fathomly is not affiliated with or endorsed by the Wikimedia Foundation. Spotted a problem? Tell us.