ML337
Pharmaceutical compound
ML337 is an experimental drug that acts as a negative allosteric modulator selective for the glutamate receptor mGluR3. It has only moderate potency with an IC50 of 450 nM, but is highly selective over the closely related subtype mGluR2 with no effect even at 30,000 nM, and so has been used to study the effects of mGluR3 in isolation, which had previously been difficult to separate from mGluR2 mediated effects.
Sources and credits
This article is adapted from the Wikipedia article “ML337”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- ML337 structure.png by Meodipt (talk), Public domain
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