Encyclopedia

MAGOH

Protein-coding gene in humans

Wikipedia contributorsAdapted for Fathomly · View authors

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Source updated September 15, 2026

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Protein mago nashi homolog is a human protein encoded by the MAGOH gene. This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

01In Drosophila

Drosophila flies produce unfit progeny when they have mutations in their mago nashi (Japanese: 孫なし, Hepburn: mago nashi; lit. 'grandchildless') gene. The progeny have defects in germplasm assembly and germline development.

02Interactions

MAGOH interacts with RBM8A and NXF1.

In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which is involved in oocyte differentiation.

Watch videos about MAGOHExplainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “MAGOH”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

The crystal structure of the human Exon Junction Complex 2J0S MAGOH.png by Bono F, Ebert J, Lorentzen E, Conti E, CC0

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