LMO4
Protein-coding gene in humans
LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.
LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.
01Clinical significance
LMO4 has garnered significant attention for its involvement in cancer, particularly breast cancer. It is overexpressed in a substantial percentage of primary breast carcinomas. Studies have shown that LMO4 can promote the proliferation of mammary epithelial cells, inhibit their differentiation, and enhance cell invasion and motility, all of which are hallmarks of cancer progression.
02Interactions
Sources and credits
This article is adapted from the Wikipedia article “LMO4”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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