LHX2
Protein-coding gene in the species Homo sapiens
LIM/homeobox 2 protein (LHX2) is a protein that in humans is encoded by the LHX2 gene and is part of the LIM gene family. LHX2, like other members of the LIM-homeobox gene family, regulates developmental processes like tissue patterning, cell fate determination and differentiation.
01Structure
LHX2 as part of the LIM gene family, it encodes for proteins with two N-terminal zinc-finger-like motifs called LIM domains and a homeobox domain. Due to the presence of the LIM domains which bind to zinc, LHX2 can form complexes like with LDB1 in mammals or binding with DNA through the HOX domain to activate genes.
02Functions
The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.
The LIM domain of LHX2 has been shown to interact with MRG1 which further binds to CITED2 and enhances transcriptional activation of the α-subunit gene of the glycoprotein hormones.
Sources and credits
This article is adapted from the Wikipedia article “LHX2”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
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