KRT86
Protein-coding gene in the species Homo sapiens
The KRT86 gene encodes for keratin, type II cuticular Hb6 protein in humans.
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRT81, KRT83, and KRT86, is highly related. The other, less-related subfamily includes KRT82, KRT84, and KRT85. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRT81 and KRT83, is found primarily in the hair cortex. Mutations in this gene and KRT81 have been observed in patients with a rare dominant hair disease, monilethrix.
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This article is adapted from the Wikipedia article “KRT86”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 12.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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