KLF12
Protein-coding gene in the species Homo sapiens
Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
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Images, from Wikimedia Commons:
- Ideogram human chromosome 13.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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