ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

One of the isoforms of ING1 (p33(ING1) is involved in the modulation of DNA repair. It appears that p33(ING1) cooperates with p53 in nucleotide excision repair. Also, proliferating cell nuclear antigen (PCNA) interacts with p33(ING1b) in the elimination of UV-damaged cells through the induction of programmed cell death (apoptosis).

ING1 is located near the following genes on Chromosome 13

• NAXD: NAD(P)HX dehydratase
• COL4A2: A2 Subunit of type IV collagen
• RAB20: Potential regulator of Connexin 43 trafficking.
• CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2

ING1 has been shown to interact with:

• CREB binding protein,
• DMAP1,
• HDAC1,
• P53,
• PCNA,
• SAP30,
• SIN3A,
• SMARCA4, and
• SMARCC1.