HSF4
Protein-coding gene in the species Homo sapiens
Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
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- Ideogram human chromosome 16.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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