Genome Project-Write
Research project to synthesise the human genome
The Genome Project-Write (also known as GP-Write) is a large-scale collaborative research project (an extension of Genome Projects, aimed at reading genomes since 1984) that focuses on the development of technologies for the synthesis and testing of genomes of many different species of microbes, plants, and animals, including the human genome in a sub-project known as Human Genome Project-Write (HGP-Write). Formally announced on 2 June 2016, the project leverages two decades of work on synthetic biology and artificial gene synthesis.
The newly created GP-Write project will be managed by the Center of Excellence for Engineering Biology, an American nonprofit organization. Researchers expect that the ability to artificially synthesize large portions of many genomes will result in many scientific and medical advances.
01Science and development
In May 2021, GP-Write and Twist Bioscience launched a new CAD platform for whole genome design. The GP-Write CAD will automate workflows to enable collaborative efforts critical for scale-up from designing plasmids to megabases across entire genomes.
02Microbial Genome Projects-Write
Technologies for constructing and testing yeast artificial chromosomes (YACs), synthetic yeast genomes (Sc2.0), and virus/phage-resistant bacterial genomes have industrial, agricultural, and medical applications.
03Human Genome Project-Write
A complete haploid copy of the human genome consists of at least three billion DNA nucleotide base pairs, which have been described in the Human Genome Project - Read program (95% completed as of 2004). Among the many goals of GP-Write are the making of cell lines resistant to all viruses and synthesis assembly lines to test variants of unknown significance that arise in research and diagnostic sequencing of human genomes (which has been exponentially improving in cost, quality, and interpretation).
Sources and credits
This article is adapted from the Wikipedia article “Genome Project-Write”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Cost per Genome.png by National Human Genome Research Institute (NHGRI) Web site genome.gov is in the public domain., CC0
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