Glycine receptor, alpha 1
Protein-coding gene in the species Homo sapiens
01Function
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed solely of alpha subunits. The GLRB gene encodes the alpha subunit of the receptor.
02Clinical significance
Mutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.
Sources and credits
This article is adapted from the Wikipedia article “Glycine receptor, alpha 1”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- PDB 1mot EBI.jpg by Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute, Public domain
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