Encyclopedia

KAT2A

Protein-coding gene in the species Homo sapiens

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Source updated June 23, 2026

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Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene.

KAT2A also acetylates non-histone proteins, including the transcription factor PAX6, promoting its ubiquitination and proteasomal degradation and thereby influencing the balance between proliferation and neuronal differentiation in neural stem cells.

01Interactions

GCN5L2 has been shown to interact with:

DDB1,
Ku70,
Ku80,
TADA2L,
TAF9, and
Transcription initiation protein SPT3 homolog.

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Sources and credits

This article is adapted from the Wikipedia article “KAT2A”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

Images, from Wikimedia Commons:

Protein GCN5L2 PDB 1f68.png by Emw, CC BY-SA 3.0

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