Gamma-aminobutyric acid receptor subunit gamma-2
Protein-coding gene in the species Homo sapiens
Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene.
01Function
Gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain, mediates neuronal inhibition by binding to GABA receptors. The type A GABA receptors are pentameric chloride channels assembled from among many genetic variants of GABA(A) subunits. This gene encodes the gamma 2 subunit of GABA(A) receptor. Mutations in this gene have been associated with epilepsy and febrile seizures. Alternative splicing of this gene results in transcript variants encoding different isoforms.
02Interactions
GABRG2 has been shown to interact with GABARAP and Dopamine receptor D5.
Sources and credits
This article is adapted from the Wikipedia article “Gamma-aminobutyric acid receptor subunit gamma-2”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 5.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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