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FCGR3B

Protein-coding gene in humans

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated September 2, 2026
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FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene.

01Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis.

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Sources and credits

This article is adapted from the Wikipedia article “FCGR3B”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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CD16

CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells. CD16 has been identified as Fc receptors FcγRIIIa and FcγRIIIb (CD16b), which participate in signal transduction.

Cluster of differentiation

The cluster of differentiation is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells. In terms of physiology, CD molecules can act in numerous ways, often acting as receptors or ligands important to the cell.