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Dimemebfe

Psychedelic drug

Wikipedia contributorsAdapted for Fathomly · View authors
1 min read
Source updated March 3, 2026
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Dimemebfe, also known as 5-methoxy-N,N-dimethyl-3-(2-aminoethyl)benzofuran (5-MeO-BFE or 5-MeO-DMBF) or as 1-oxa-5-MeO-DMT, is a psychedelic drug of the benzofuran family related to the psychedelic tryptamine 5-MeO-DMT. It is the analogue and bioisostere of 5-MeO-DMT in which the nitrogen atom of the indole ring has been replaced with an oxygen atom, making dimemebfe a benzofuran rather than tryptamine derivative. The drug has been encountered as a novel designer drug.

01Pharmacology

Pharmacodynamics

Dimemebfe acts as an agonist of the serotonin 5-HT1A and 5-HT2 family of serotonin receptors. It is several times less potent as a serotonin receptor agonist than 5-MeO-DMT and with relatively more activity at the serotonin 5-HT1A receptor, but still shows strongest actions at the 5-HT2 family of receptors.

02Chemistry

Synthesis

The chemical synthesis of dimemembfe has been described.

Analogues

Analogues of dimemebfe include the benzofurans 5-MeO-DiBF (1-oxa-5-MeO-DiPT), 3-APB (1-oxa-AMT), and mebfap (5-MeO-3-APB; 1-oxa-5-MeO-AMT), the benzothiophene S-DMT (1-thia-DMT), and the tryptamine 5-MeO-DMT, among others.

03History

Dimemebfe was first described in the scientific literature by David E. Nichols and colleagues in 1992. Subsequently, it emerged as a novel designer drug by 2012.

04Society and culture

Legal status

Canada

Dimemebfe is not a controlled substance in Canada as of 2025.

United States

Dimemebfe is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

Dimemebfe is a Schedule I controlled substance in the United States state of Alabama.

Watch videos about DimemebfeExplainers and documentaries on YouTube (opens in a new tab)

Sources and credits

This article is adapted from the Wikipedia article “Dimemebfe”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.

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Related topics

Substituted benzofuran

The substituted benzofurans are a class of chemical compounds based on the heterocyclic and polycyclic compound benzofuran. Many medicines use the benzofuran core as a scaffold, but most commonly the term is used to refer to the simpler compounds in this class which include numerous psychoactive drugs, including stimulants, psychedelics and empathogens.

Substituted tryptamine

Substituted tryptamines, or simply tryptamines, also known as serotonin analogues, are organic compounds which may be thought of as being derived from tryptamine itself. The molecular structures of all tryptamines contain an indole ring system, joined to an amino (NH2) group via an ethyl (−CH2-CH2−) sidechain.