DOC2B
Protein-coding gene in the species Homo sapiens
Double C2-like domain-containing protein beta is a protein that in humans is encoded by the DOC2B gene.
01Function
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. In mouse and rat tissue, Doc2b enhances Ca2+-dependent exocytosis in adipocytes, chromaffin cells of the adrenal gland and beta cells in the pancreas. In the central nervous system, Doc2b contributes to the spontaneous release of neurotransmitters, which was thought to be acting as a high-affinity Ca2+ sensor for exocytosis of synaptic vesicles However, further work has shown that while DOC2b is both important for spontaneous exocytosis of synaptic vesicles and binds Calcium, it does not in fact change the calcium dependence of spontaneous synaptic vesicle release and thus can not be the calcium sensor for this process.
Sources and credits
This article is adapted from the Wikipedia article “DOC2B”, written by its contributors and licensed under CC BY-SA 4.0. Fathomly has changed the layout, removed citation markers, navigation and maintenance notices, and adjusted punctuation. This adapted version is shared under the same license. For references, see the original article.
Images, from Wikimedia Commons:
- Ideogram human chromosome 17.svg by National Center for Biotechnology Information, U.S. National Library of Medicine, Public domain
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